This paper is only available as a PDF. To read, Please Download here.
Abstract
Norgestrienone implants delivering approximately 225 μg/day were tested clinically
for contraceptive effectiveness and acceptability in 145 women. Five pregnancies occurred
in 2259 woman-months of use, one in the 11th month, one in the 15th and three in the
16th month of use. Continuation rate at 12 months was 86.7. The number of bleeding
runs and bleeding days was increased in approximately 12% of the subjects. Ten percent
of the patients had no bleeding in the first 90 days of treatment. Changes in bleeding
pattern led to closures in four cases. Headache and signs of mild androgenicity were
among the leading side effects. Blood and urine analysis throughout the study showed
normal values of 17 different parameters, but a tendency to lower cholesterolemia
not associated with changes in thyroid hormone levels, was observed in several patients.
Cortisol was found slightly under the lower normal range in one subject without clinical
manifestations of hypoadrenalism. It is concluded that norgestrienone implants should
be replaced every twelve months for maximal contraceptive effect and because of their
efficacy and good acceptability, evaluation of their long term use is warranted.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to ContraceptionAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- One year contraception with norgestrienone subdermal silastic implants.Fertil. Steril. 1974; 25: 170
- Clinical trial with subdermal implants of the progestin R 2323.Contraception. 1977; 16: 155
- Enfoque al analisis de patrones menstruales en la evaluaxion critica de anticonceptivos.Estudios de Poblacion. 1976; 1: 90
- Incidencia de litiasis biliar en material de autopsias y analisis de la composicion de los calculos.Rev. Med. Chile. 1972; 100: 1320
Nash, H.A., Robertson, D.N., Moo Young, A.J. and Atkinson, L.E., Steroid release from silastic capsules and rods. Contraception, this issue.
Article info
Publication history
Accepted:
September 1,
1978
Identification
Copyright
© 1978 Published by Elsevier Inc.
