Clinical trial with subdermal implants containing norgestrienone

      This paper is only available as a PDF. To read, Please Download here.


      Norgestrienone implants delivering approximately 225 μg/day were tested clinically for contraceptive effectiveness and acceptability in 145 women. Five pregnancies occurred in 2259 woman-months of use, one in the 11th month, one in the 15th and three in the 16th month of use. Continuation rate at 12 months was 86.7. The number of bleeding runs and bleeding days was increased in approximately 12% of the subjects. Ten percent of the patients had no bleeding in the first 90 days of treatment. Changes in bleeding pattern led to closures in four cases. Headache and signs of mild androgenicity were among the leading side effects. Blood and urine analysis throughout the study showed normal values of 17 different parameters, but a tendency to lower cholesterolemia not associated with changes in thyroid hormone levels, was observed in several patients. Cortisol was found slightly under the lower normal range in one subject without clinical manifestations of hypoadrenalism. It is concluded that norgestrienone implants should be replaced every twelve months for maximal contraceptive effect and because of their efficacy and good acceptability, evaluation of their long term use is warranted.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Contraception
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Coutinho E.M.
        • Da Silva A.R.
        One year contraception with norgestrienone subdermal silastic implants.
        Fertil. Steril. 1974; 25: 170
        • Diaz S.
        • Pavez M.
        • Quinteros E.
        • Robertson D.N.
        • Croxatto H.B.
        Clinical trial with subdermal implants of the progestin R 2323.
        Contraception. 1977; 16: 155
        • Rodriguez G.
        • Faundes A.L.
        • Atkinson L.E.
        Enfoque al analisis de patrones menstruales en la evaluaxion critica de anticonceptivos.
        Estudios de Poblacion. 1976; 1: 90
        • Marinovic I.
        • Guerra C.
        • Larach G.
        Incidencia de litiasis biliar en material de autopsias y analisis de la composicion de los calculos.
        Rev. Med. Chile. 1972; 100: 1320
      1. Nash, H.A., Robertson, D.N., Moo Young, A.J. and Atkinson, L.E., Steroid release from silastic capsules and rods. Contraception, this issue.