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Abstract
To study the question of whether one brand of oral contraceptives may be as acceptable
as another for use in publicly-assisted family planning programs, a double blind study
of two well-known brands, Ovral and Norinyl, was undertaken in Costa Rica and Trinidad.
The pills were randomly assigned to 1,200 women. Common side effects — nausea, dizziness,
vomiting, headaches — were associated with both Norinyl and Ovral. Differences in
event rates for these conditions were much more marked by country than by the pill
used. Ovral was associated with increases in skin problems, notably chloasma, in Costa
Rica. A higher percentage of women using Norinyl reported intermenstrual bleeding
and spotting in both countries. In Costa Rica continuation rates for Norinyl were
adversely affected by this. With these exceptions there appear to be no important
differences between the brands that would affect their use in family planning programs.
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References
- Use-effectiveness of intrauterine contraception as a problem of competing risks.in: Freedman R. Takeshita J.Y. Family Planning in Taiwan, and experiment in social change. Princeton University, 1969: 458-484
- Statistical Evaluation of Contraceptive Methods.Clinical Obstetrics and Gynecology. March, 1978; 17: 121-138
- Life-Table Analysis of IUDs: Problems and Recommendations.Studies in Family Planning. 1977; Vol. 8
- A new procedure for the statistical evaluation of intrauterine contraception.Am.J. Obstet. Gynecol. 1977; 128: 329
- A comparison of symptoms associated with the use of three oral contraceptives: a double-blind crossover study of Ovral, Norinyl, and Norlestrin.Advances in Planned Parenthood. 1978; Vol. XII
Article info
Publication history
Accepted:
June 6,
1979
Identification
Copyright
© 1979 Published by Elsevier Inc.
