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Abstract
Previous studies showed that the two forms of momorcharins which are isolated from
seeds of
L. are effective in inducing early and midterm abortions in the mouse. Momorcharins
were found to be teratogenic to the cultured mouse embryos at the early organogenesis
stage. Morphological abnormalities were seen in the head, trunk and limbs. Ultrastructural
studies on the visceral yolk sac of the momorcharin-treated embryos showed that the
endodermal layer was deranged, membrane invaginations at the apical surface were decreased
and intercellular space became distended. It is likely that the teratogenic action
of momorcharins on mouse embryos
is mediated through the deleterious effects on the visceral yolk sac, which functions
as a vital transport organ for the conceptus at the immediate post-implantation period.


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Article info
Publication history
Accepted:
October 21,
1986
Received:
September 30,
1986
Identification
Copyright
© 1986 Published by Elsevier Inc.