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Abstract
In this study the variations of endocrine and metabolic parameters of 39 women treated
with a new oral contraceptive combination containing 20 mcg of ethinylestradiol and
150 mcg of desogestrel were examined.
Gonadotropins and androgen presented a significant decrease, showing the efficiency
of suppression of the pituitary-ovarian activity and of the contraceptive effect.
The significant increase of SHBG and the correspoding reduction of free testosterone
reflect the estrogenic environment of this pill and the low androgenicity of desogestrel.
During the observation period, plasma levels of total cholesterol, trglycerides, LDL-C
and HDL2-C were not altered, whereas total phospholipids, HDL-C and HDL3-C increased
significantly. Besides a general positive effect on the main lipid parameters involved
in atherogenic process, this pill also presented an optimal subjective tolerability.
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Article info
Publication history
Accepted:
October 26,
1987
Received:
August 5,
1987
Identification
Copyright
© 1987 Published by Elsevier Inc.