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Abstract
Ten doses of 7.5mg Anordrin were administered on alternate days from day 5 of the
menstrual cycle to 20 women. Serum concentrations of both SHBG and CP were significantly
increased after the fourth dose but the increases were minor compared to those produced
by ethynyloestradiol. Two weeks after stopping Anordrin, serum concentrations of the
proteins were still elevated in most women. Ovarian activity was studied in 8 women;
serum oestradiol and progesterone concentrations indicated that ovulation occurred
at the normal time in three women but was delayed for two weeks or more in the remaining
five. The findings suggest that in humans, Anordrin acts as a weak oestrogen and may
also have antioestrogenic activity.
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Article info
Publication history
Accepted:
October 28,
1987
Received:
September 23,
1987
Identification
Copyright
© 1987 Published by Elsevier Inc.
