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Abstract
Pregnancy was interrupted in Swiss-Rockefeller mice by a single subcutaneous injection
of the antiprogesterone RU486 given postcoitally. A dose of 0.1 mg/animal injected
on day 1, produced partial inhibition of pregnancy, a notable delay in embryonic development
and a slight retention of embryos in the oviducts. When the same dose was injected
on day 2, 3 or 4, no implantation sites were seen at autopsy performed on day 12 of
pregnancy. Treatment with 0.5 or 1 mg/animal on day 1 produced the loss of a large
proportion of the embryos from the genital tract by day 4 of pregnancy and suppressed
implantation completely. These observations indicate that preimplantation phenomena
in mice are highly dependent on progesterone action.
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References
- Investigation of the influence of progesterone on mouse embryo transport by using antiprogestational steroid.J Reprod Fert. 1980; 58: 253
- Action of anti-progesterone monoclonal antibody in blocking pregnancy after postcoital administration in mice.J Endocr. 1984; 101: 95
- Pharmacological profile of RU486 in animals.in: Balieu E-E. Segal S.J. The Antiprogestin Steroid RU486 and Human Fertility Control. Plenum Press, New York1985: 49-68
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- Effect of oestradiol-17B and progesterone on oviductal transport and early development of mouse embryos.J Reprod Fert. 1979; 57: 91
- Effect of postcoital oestradiol treatment upon transport, growth, differentiation and viability of preimplantation mouse embryos.Arch Biol Med Exp. 1983; 16: 55
Article info
Publication history
Accepted:
November 30,
1987
Received:
August 20,
1987
Identification
Copyright
© 1987 Published by Elsevier Inc.
