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Abstract
The effect of DL-204, 2-(3-ethoxyphenyl)-5,6-dihydro-5-triazole (5,1a)-isoquinoline,
a non-hormonal post-implantational anti-fertility drug, on tissue weights, nucleic
acids and total protein concentrations in the testes, ventral prostate and seminal
vesicles were evaluated in immature and sexually mature rats, while changes in DNA
synthesis were studied only in the immature rats. Treatment of 21-day-old rats at
doses of 5mg and 10mg/kg bw once daily for 15 days had no effect on body weight but
reduced the weights of testes and accessory glands of reproduction. The concentration
of DNA increased while RNA and protein decreased significantly. Treatment of adult
rats with DL-204 at a dose of 10mg/kg bw had no effect on body and testes weights
but reduced ventral prostate and seminal vesicle weights. The concentration of RNA
and protein decreased significantly, while DNA concentration was not altered. DL-204
treatment resulted in drastic decrease of RNA/DNA ratio, reflecting ribosomal loss
and cytoplasmic shrinkage. The effects observed after DL-204 treatment are comparable
to post-castration changes. DL-204 may be acting on testes and accessory reproductive
organs by blocking androgen biosynthesis and/or by antagonizing the action of androgens.
It may be acting directly on the normal function of the hypothalamo-pituitary-gonadal
axis.
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Article info
Publication history
Accepted:
November 30,
1987
Received:
July 7,
1987
Identification
Copyright
© 1987 Published by Elsevier Inc.
