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Abstract
Effects of DL-204, 2-(3-ethoxyphenyl)-5,6-dihydro (5,1-a)-isoquinoline, a non-hormonal
antifertility drug on testicular hyaluronidase and gammaglutamyl transpeptidase levels,
biochemical markers for testicular function, were evaluated in male rats. Treatment
of 21-day-old rats with DL-204 for 7 or 15 days produced cryptorchid condition. Testicular
hyaluronidase and gamma-glutamyl transpeptidase levels reveal that DL-204 acts on
the testes, possibly in two ways; one, by reducing the gonadotropin levels thereby
reducing the levels of androgens as reflected by reduced accessory reproductive organ
weights and, secondly, by a direct action on the testes. Thus, we conclude that DL-204
is acting as an antispermatogenic agent, possibly acting in more than one way on the
testes.
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Article info
Publication history
Accepted:
November 30,
1987
Received:
July 7,
1987
Identification
Copyright
© 1987 Published by Elsevier Inc.