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Abstract
In this longitudinal study involving 100 Singaporean acceptors, the effects of Norplant®-2
rods on metabolic function was evaluated. With respect to liver function, the results
indicate possible hepatocellular dysfunction. There was a significant rise in mean
serum bilirubin from 0.54 mg/dl to 0.85 mg/dl after 12 months of use (p < 0.001). Furthermore, there was also a significant fall in total proteins from 7.37
gm/dl to 7.12 gm/dl (p < 0.001) and serum globulin from 3.18 gm/dl to 2.84 gm/dl (p < 0.001).
As regards lipid metabolism, we have demonstrated significant decreases in mean serum
triglycerides (1.04 mmol/l to 0.83 mmol/l), p < 0.001; total cholesterol (5.04 mmol/l to 4.64 mmol/l), p < 0.001; and LDL-cholesterol (3.36 mmol/l to 3.10 mmol/l), p < 0.001 after one year of use. There was a small fall in the HDL-cholesterol (1.21
mmol/l to 1.16 mmol/l) after 12 months of use; this fall was not significant. Despite
this, there was a rise in the HDL-cholesterol/Total cholesterol -HDL-cholesterol ratio
(0.258 cf 0.244; p < 0.05) after 1 year of use. As we have not incorporated a simultaneous non-pill
treated control group, the observed changes in lipoprotein lipids could be attributed
to extraneous factors such as diet, exercise or other environmental changes. Nevertheless,
the findings, though speculative, indicate Norplant®-2 use to be non-contributory
to cardiovascular risk and indeed it may be a protective factor against such risks
in this population. The use of Norplant®-2 rods was not associated with any significant
effect on glucose tolerance after 12 months of use.
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Article info
Publication history
Accepted:
July 22,
1988
Received:
May 11,
1988
Identification
Copyright
© 1988 Published by Elsevier Inc.
