Pharmacokinetic study of orally administered RU 486 in non-pregnant women

References

1. • Baulieu EE
   RU 486: an antiprogestin steroid with contragestive activity in women.
   in: Baulieu EE Segal SJ The antiprogestin steroid RU 486 and human fertility control. Plenum Press, New York1985: 1-25
   • Google Scholar
2. • Herrmann W
   • Wyss R
   • Riondel A
   • et al.
   Effet d'unstéroide anti-progestérone chez la femme: interruption du cycle menstruel et de la grossesse au début.
   CR Acad Sci (Paris). 1982; 294: 933-938
   • Google Scholar
3. • Kovacs L
   • Sas M
   • Resch BA
   • et al.
   Termination of very early pregnancy by RU 486 -an antiprogestational compound.
   Contraception. 1984; 29: 399-410
   • Google Scholar
4. • Mishell Jr, DR
   • Shoupe D
   • Brenner PF
   • et al.
   Termination of early gestation with the anti-progestin steroid RU 486: medium versus low dose.
   Contraception. 1987; 35: 307-321
   • Google Scholar
5. • Birgerson L
   • Odlind V
   Early pregnancy termination with antiprogestins: a comparative clinical study of RU 486 given in two dose regimens and Epostane.
   Fertil Steril. 1987; 48: 565-570
   • Google Scholar
6. • Van Look PFA
   • Bygdeman M
   Antiprogestational steroids: a new dimension in human fertility regulation.
   in: 8 Aufl. Oxford Reviews of Reproductive Biology. Vol. 11. Oxford University Press, Oxford1989 (in press)
   • Google Scholar
7. • Ye Z
   • Zhang G
   • Bai X
   High performance liquid chromatographic determination of RU 486 in human plasma.
   Chin J Chromatogr. 1987; 3: 179-182
   • Google Scholar
8. • Deraedt R
   • Bonnat C
   • Busigny M
   • et al.
   Pharmacokinetics of RU 486.
   in: Baulieu EE Segal SJ The antiprogestin steroid RU 486 and human fertility control. Plenum Press, New York1985: 103-122
   • Google Scholar
9. • Swahn ML
   • Cekan S
   • Wang G
   • Lundstrom V
   • Bygdeman M
   Pharmacokinetic and clinical studies of RU 486 for fertility regulation.
   in: Baulieu EE Segal SJ The antiprogestin steroid RU 486 and human fertility control. Plenum Press, New York1985: 249-258
   • Google Scholar
10. • Heikinheimo O
    • Tevilin M
    • Shoupe D
    • Croxatto H
    • Lähteenmäki P
    Quantitation of RU 486 in human plasma by HPLC and RIA after column chromatography.
    Contraception. 1986; 34: 613-624
    • Google Scholar
11. • Heikinheimo O
    • Kontula K
    • Croxatto H
    • Spitz I
    • Luukkainen T
    • Lähteenmäki P
    Plasma concentrations and receptor binding of RU 486 and its metabolites in humans.
    J Steroid Biochem. 1987; 26: 279-284
    • Google Scholar
12. • Kawai S
    • Nieman LK
    • Brandon DD
    • Udelsman R
    • Loriaux DL
    • Chrousos GP
    Pharmacokinetic properties of the antiglucocorticoid and antiprogesterone steroid RU 486 in man.
    J Pharmacol Exp Ther. 1987; 241: 401-406
    • Google Scholar
13. • Lähteenmäki P
    • Heikinheimo O
    • Croxatto H
    • et al.
    Pharmacokinetics and metabolism of RU 486.
    J Steroid Biochem. 1987; 27: 859-863
    • Google Scholar
14. • Liu JH
    • Garzo VG
    • Yen SSC
    Pharmacodynamics of the antiprogesterone RU486 in women after oral administration.
    Fertil Steril. 1988; 50: 245-249
    • Google Scholar
15. • Heikinheimo O
    Pharmacokinetics of the antiprogesterone RU 486 in women during multiple dose administration.
    J Steroid Biochem. 1989; 32: 21-25
    • Google Scholar
16. • Gao J
    • Qiao G-M
    • Wu Y-M
    • et al.
    Pregnancy interruption with RU 486 in combination with dl-15-methyl-prostaglandin F_2α methyl ester: the Chinese experience.
    Contraception. 1988; 38: 675-683
    • Google Scholar
17. • Heikinheimo O
    • Lähteenmäki PLA
    • Koivunen E
    • et al.
    Metabolism and serum binding of RU 486 in women after various single doses.
    Hum Reprod. 1987; 2: 379-385
    • Google Scholar