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Abstract
A longitudinal study was undertaken to assess PRL, cortisol, TSH, T3 and T4 levels in NORPLANT4 implant users (n = 22) and Copper T users (n = 20). Participants were healthy women with no contraindication for hormonal contraception.
Samples were drawn at 0930 to 1000 h twice pretreatment and at month 2, 4, 6, 12,
24 and 36 after insertion. At the second treatment month, a second sample was obtained
at 1600 h to assess cortisol diurnal variation. Hormones were measured by RIA.
Values for all hormones were similar in NORPLANTR and Copper T users. No significant changes occurred throughout the study period.
Elevated PRL levels (>500 mU/1) were found in three women from each group before and
during treatment but no clinical evidence of hyperprolactinemia was detected.
The results of this study reassure that long-term use of NORPLANTR implants do not impair plasma levels of cortisol, prolactin and thyroid hormones.
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Article info
Publication history
Accepted:
July 7,
1989
Received:
March 31,
1989
Identification
Copyright
© 1989 Published by Elsevier Inc.
