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Abstract
Many of the common polyphenolic compounds which are naturally present in abundance
in plant extracts, exercise inhibitory effects on mammalian sperm motility
, which could be the cause of the antifertility effects of the crude plant extracts.
The action of these polyphenolic compounds seems to be structure-dependent. Their
activity was found to be dependent on the positions of hydroxyl groups and modulated
by the positions of methyl groups on the benzene ring. Carbon-carbon double bond on
the side chain of cinnamic acid series compounds was essential for their activity.
One of the plausible actions of polyphenols on spermatozoa seems to be the augmentation
of the generation of superoxide radicals by them, which might be involved in the inhibition
of their motility
.


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Article info
Publication history
Accepted:
February 28,
1989
Received:
December 6,
1988
Identification
Copyright
© 1989 Published by Elsevier Inc.