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Abstract
The use of gemeprost (16, 16-dimethyl-trans- Δ2-PGE1 methyl ester) vaginal pessaries for the termination of pregnancy in the late
second trimester has been investigated in an open single-center study. Of 56 nulliparous
women between 18 and 22 weeks amenorrhoea, 33 (58.9%) aborted after the administration
of 1 mg gemeprost pessaries; 5 women did abort after 3 doses, 10 after 4 doses and
18 after 5 doses. There was no statistical correlation between gestational age and
abortion. The mean induction-abortion interval was 15.2 hrs (range 8.5–20.3 hrs).
There were no serious complications. The safe induction of therapeutic abortion in
58.9% of women using vaginal gemeprost pessaries alone offers an acceptable alternative
to surgical evacuation in the late second trimester but should not be started without
the possibility to terminate the procedure by dilatation and evacuation (D + E).
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References
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Article info
Publication history
Accepted:
April 4,
1990
Received:
October 16,
1989
Identification
Copyright
© 1990 Published by Elsevier Inc.
