Original research article| Volume 51, ISSUE 1, P19-24, January 1995

A changing pattern in the association of oral contraceptives and the different groups of congenital limb deficiencies

  • Andrew E. Czeizel
    Address for correspondence and reprint requests: Dr. Andrew E. Czeizel, Department of Human Genetics and Teratology, National Institute of Hygiene, 1097 Budapest, Gyáli U. 2-6, Hungary
    Department of Human Genetics and Teratology, National Institute of Hygiene—WHO Collaborating Centre for the Community Control of Hereditary Diseases, Budapest, Hungary
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  • Imre Kodaj
    Department of Gynecology and Obstetrics, State Hospital, Budapest, Hungary
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      A case-control study on different groups of isolated congenital limb deficiency was performed in a ten-year population-based and revised Hungarian data set. A higher rate of one contraceptive pill type with relatively high dose (ethynodiol diacetate 1.0 mg + ethinyloestradiol 0.05 mg) used in the periconceptional period was found in the mothers of cases with terminal transverse defect (adjusted relative odds 1.9 with 95% confidence interval of 1.1–3.4). This risk is minimised by the use of recent low-dose pills.


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