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Abstract
Antifeitility effects of intrauterine neem treatment (IUNT) was studied in bonnet
monkeys. A single administration of 1 ml of neem oil by an intrauterine insemination
catheter blocked fertility for 7 to 12 months. The effect was, however, reversible
as all the animals became pregnant subsequently and delivered normal babies. The neem
oil treatment had no adverse effect on menstrual cyclicity and ovarian functions.
The uterus of neem-treated animals showed normal morphology. Immunohistological studies,
however, demonstrated a significant increase in the number of MHC-II antigen-positive
cells in the uterine endometrium following neem treatment, indicating enhanced antigen-presenting
ability of the uterus; a feature that may be related to the observed antifertility
effect of neem oil. The present investigation demonstrates that an IUNT can be used
for long-term, reversible contraception, without any apparent side effects, and that
the method could provide an alternate to currently used intrauterine contraceptive
devices (IUCD).
Keywords
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Article info
Publication history
Accepted:
November 15,
1993
Received:
June 4,
1993
Identification
Copyright
© 1994 Published by Elsevier Inc.
