Abstract
The contraceptive efficacy and safety of a progesterone-releasing vaginal ring (PVR)
manufactured in Chile were compared to that of the Copper T 380A IUD (T-Cu) in nursing
women enrolled at three Chilean clinics. A total of 285 volunteers chose to use the
PVR and 262 the T-Cu. Plasma progesterone levels attained with the ring decreased
from 25 to 14 nmol/L from month 1 to month 3 of use. Ring replacement was scheduled
every 3 months. Volunteers continued in the study until weaning or completing the
continuous use of four PVRs. No pregnancies occurred in 2320 and 2183 woman-months
of exposure with the PVR and the T-Cu, respectively. Lower continuation rates in the
first 6 months because of problems with use and a longer lactational amenorrhea were
observed in the PVR than in the T-Cu group. Breast-feeding performance and infant
growth were similar in both groups. These results confirm the high efficacy and safety
of the PVR for nursing women and have led to the registration of the PVR by Chilean
health authorities.
Keywords
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Article info
Publication history
Accepted:
June 21,
1999
Received in revised form:
April 5,
1999
Received:
October 2,
1998
Identification
Copyright
© 1999 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.
