Abstract
Lipocalin type prostaglandin-D-synthase (L-PGDS), also called β-trace, is an extracellular
protein very abundant in compartments beyond blood-tissue barriers, such as the cerebrospinal
fluid, the aqueous humor, the amniotic fluid and the seminal fluid. In the latter
fluid the major function of L-PGDS does not seem to be the synthesis of prostaglandin
D2 (PGD2) from its precursor PGH2, which is very unstable in aqueous solution. Instead, seminal L-PGDS, an important
carrier of bile pigments, retinoids, thyroid hormones and essential fatty acids, would
contribute to providing, beyond the blood-testis barrier, thyroid hormones and retinoids
to the developing germ cells in the seminiferous tubules and the maturing spermatozoa
in the epididymis.
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© 2002 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.
