Abstract
This study evaluated contraception by formulated Ushercell���, a uniquely high-molecular-weight
form of cellulose sulfate, in the rabbit. Variables included (1) dose effectiveness,
(2) duration of effectiveness, and (3) formulation excipients. Vaginally applied carboxymethyl-cellulose-based
Ushercell��� gel is contraceptive. A 6% gel is active for at least 18 h; partial activity
is observed for at least 24 h. With an application���insemination interval of 0.5
h, Ushercell��� as low as 0.1% is contraceptive. Contraception is incomplete with
2% Ushercell��� and an application���insemination interval of 24 h. Ushercell��� formulations
containing a relatively high concentration of Carbopol are ineffective contraceptives,
whether the gel is applied before insemination or is premixed with spermatozoa before
insemination. Contraceptive activity is restored in Ushercell��� formulations with
lower Carbopol content. This study shows that formulated Ushercell��� is an effective,
long-lasting contraceptive and, hence, is bioavailable when vaginally applied. Activity
is dependent on the type and relative concentration of formulation excipients. These
data support a projected successful outcome of further clinical trials.
Keywords
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Article info
Publication history
Accepted:
May 24,
2004
Received in revised form:
May 12,
2004
Received:
April 4,
2004
Identification
Copyright
© 2004 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
