Abstract
This open-label, randomized study compared the pharmacokinetics of ethinylestradiol
(EE) from the contraceptive vaginal ring NuvaRing (15 ��g EE/day), the transdermal
patch (20 ��g EE/day) and a combined oral contraceptive (COC) containing 30 ��g EE.
After 2���8 weeks of synchronization by COC treatment, subjects were randomized to
21 days of treatment with NuvaRing, patch or COC. Analysis of area under the EE concentration-versus-time
curve (AUC) during 21 days of treatment showed that exposure to EE in the NuvaRing
group was 3.4 times lower than in the patch group (p<.05) and 2.1 times lower than
in the pill group (p<.05). Serum EE levels of subjects showed much lower variation
with NuvaRing than with the patch or the COC. Thus, exposure to EE was significantly
lower with NuvaRing than with the patch and pill methods, demonstrating that NuvaRing
is a low-estrogen-dose contraceptive method that also results in low estrogen exposure.
Keywords
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References
- Pharmacokinetics of etonogestrel and ethinylestradiol released from a combined contraceptive vaginal ring.Clin Pharmacokinet. 2000; 39: 233-242
- Efficacy, tolerability and acceptability of a novel contraceptive vaginal ring releasing etonogestrel and ethinyl oestradiol.Hum Reprod. 2001; 16: 469-475
- Efficacy, cycle control, and user acceptability of a novel combined contraceptive vaginal ring.Obstet Gynecol. 2002; 100: 585-593
- Multiple-dose pharmacokinetics of a contraceptive patch in healthy women participants.Contraception. 2001; 64: 287-294
- Pharmacokinetics of levonorgestrel and ethinylestradiol in 9 women who received a low-dose oral contraceptive over a treatment period of 3 months and, after a wash-out phase, a single oral administration of the same contraceptive formulation.Contraception. 1992; 46: 455-469
- Ziprasidone and the pharmacokinetics of a combined oral contraceptive.Br J Clin Pharmacol. 2000; 49: 49S-56S
- Pharmacokinetics of a contraceptive patch (Evra/Ortho Evra) containing norelgestromin and ethinyloestradiol at four application sites.Br J Clin Pharmacol. 2002; 53: 141-146
- The combined oral contraceptive. Risks and adverse effects in perspective.Drug Saf. 1995; 12: 91-96
- Oral contraceptive estrogen dose considerations.Contraception. 1998; 58: 15S-21S
- Comparison of cycle control with a combined contraceptive vaginal ring and oral levonorgestrel/ethinyl estradiol.Am J Obstet Gynecol. 2002; 186: 389-395
- Superior cycle control with a contraceptive vaginal ring compared with an oral contraceptive containing 30 ��g ethinylestradiol and 150 ��g levonorgestrel: a randomized trial.Hum Reprod. 2005; 20: 557-562
Article Info
Publication History
Published online: June 17, 2005
Accepted:
March 15,
2005
Received:
February 5,
2005
Identification
Copyright
© 2005 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
