Abstract
Objectives
Extensive data from clinical trials document mifepristone's safety and efficacy for
induced abortion, but less information is available about its safety in routine clinical
use.
Methods
Data on mifepristone abortion use from the Planned Parenthood Federation of America,
the largest provider of mifepristone abortion in the United States, from 2001 through
the first quarter of 2004 were collected using a centralized reporting system. Over
the study period, 95,163 mifepristone abortions were provided. Reportable events are
complications requiring inpatient or outpatient hospital treatment.
Results
Overall, 2.2 per 1000 women (95% CI 1.9���2.5) experienced a complication, most commonly,
heavy bleeding. Mifepristone abortion mortality is estimated to be 1.1 per 100,000
based on one death (95% CI 0.3���5.9).
Conclusions
The safety of mifepristone is high; few serious medical complications occur in routine
clinical use.
Keywords
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Article info
Publication history
Published online: June 16, 2005
Accepted:
March 22,
2005
Received in revised form:
March 18,
2005
Received:
January 7,
2005
Identification
Copyright
© 2005 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
