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Postcoital ingestion of the aqueous extract of Erythrina falcata Benth prevents pregnancy in the mouse

  • Pedro A. Orihuela
    Correspondence
    Corresponding author. Unidad de Reproducci��n y Desarrollo, Facultad de Ciencias Biol��gicas, Pontificia Universidad Cat��lica de Chile, Casilla 114-D, Santiago, Chile. Tel.: +56 2 6862871; fax: +56 2 2225515.
    Affiliations
    Laboratorio de Reproducci��n y Biolog��a del Desarrollo, Facultad de Ciencias Biol��gicas, Universidad Nacional Mayor de San Marcos, Lima, Per��
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  • Author Footnotes
    1 Deceased on January 25, 2004.
    Victor Ishiyama
    Footnotes
    1 Deceased on January 25, 2004.
    Affiliations
    Laboratorio de Reproducci��n y Biolog��a del Desarrollo, Facultad de Ciencias Biol��gicas, Universidad Nacional Mayor de San Marcos, Lima, Per��
    Search for articles by this author
  • Author Footnotes
    1 Deceased on January 25, 2004.

      Abstract

      Aim

      We examined whether the aqueous extract of Erythrina falcata, reputed to be a contraceptive in Peruvian folklore, could prevent pregnancy in the mouse.

      Methods

      Female mice on Day 1 of pregnancy were given aqueous extract of E. falcata or tap water (control) orally for 4 days. On Day 4 of pregnancy, animals were killed and the embryos were flushed from oviducts and uterus to examine their developmental stage, cell number, mitotic index and micronuclei frequency. Other mice were killed on Day 12 of pregnancy to determine the number of implantation sites.

      Results

      Ingestion of E. falcata diminished the percentage of embryos that progressed to blastocyst stage, reduced the cell number and mitotic index, and increased the micronuclei frequency of early embryos. The number of implantation sites was also reduced in females treated with E. falcata.

      Conclusion

      The aqueous extract of E. falcata, ingested during early pregnancy, disturbs preimplantation embryo development and implantation in the mouse. These results provide the first experimental evidence of the contraceptive properties of the aqueous extract of E. falcata.

      Keywords

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