This prospective noncomparative observational study evaluated the clinical symptoms, body weight and blood pressure of 38 adolescents receiving a monthly injectable contraceptive containing estradiol valerate 5 mg and norethisterone 50 mg.
The volunteers, aged 16���19 years, were examined monthly during 1 year and asked about the following symptoms at baseline: dysmenorrhea, headache, breast tenderness, leg pain and irritability.
There was a constant and gradual decline in each of the above symptoms over time, and there was a statistically significant difference between symptoms reported at the first visit and subsequent appointments. Body weight and blood pressure did not change significantly during the 1-year period. No pregnancies were observed.
These findings suggest that monthly injectable contraception with estradiol valerate 5 mg/norethisterone 50 mg represents a highly effective and well-tolerated contraceptive for teens.
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Published online: May 26, 2007
Accepted: March 12, 2007
Received in revised form: January 18, 2007
Received: December 16, 2006
���Financial support: the injections were provided, free of charge, by Schering Brasil (Schering, Berlin, Germany) to the Family Planning Clinic. No other funding was received, from Schering or any other industry or agency, in support of this research. There was no conflict of interest by any of the authors.
© 2007 Published by Elsevier Inc.