Abstract
Purpose
The aim of this study was to compare effects of the transdermal contraceptive patch,
a desogestrel/ethinyl estradiol (EE)-containing, monophasic combination oral contraceptive
(COC) and a levonorgestrel/EE-containing, triphasic COC on hemostasis variables.
Study Design
This was a randomized, open-label study of 104 young women who received six cycles
of treatment. Blood was collected at baseline and on treatment; changes by Day 20/Cycle
6 in baseline hemostasis markers [prothrombin fragment 1+2 (F 1+2), plasmin���plasmin
inhibitor complex (PAP) and fibrin degradation products (d-dimer)] were assessed.
Results
All contraceptives induced similar increases in F 1+2 and d-dimer. Patch-induced PAP increases were less than with the monophasic and similar
to the triphasic COC. Decreases in protein S and increases in sex hormone-binding
globulin were greater with the patch than with either COC. Patch-induced increases
in activated protein C resistance were greater than with the triphasic and similar
to the monophasic COC.
Conclusion
These contraceptives appeared to accelerate baseline procoagulation processes to a
similar extent and to change coagulation potency variables differently.
Keywords
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Article info
Publication history
Published online: January 15, 2008
Accepted:
October 20,
2007
Received in revised form:
October 19,
2007
Received:
June 14,
2007
Footnotes
���This study was funded by Ortho Women's Health and Urology.
Identification
Copyright
© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
