Abstract
Background
A number of copper-bearing intrauterine devices (Cu-IUDs) are now commercially available
in China. The release behavior of cupric ion from Cu-IUDs is essential to the success
of contraception, and the release behavior of indomethacin from medicated Cu-IUD is
related to its therapeutic effect.
Study Design
In this study, analytical methods were established to investigate the release behavior
of cupric ion of three existing types of Cu-IUDs and indomethacin of one medicated
Cu-IUD (Yuangong 365 Cu-IUD). Cu-IUDs were incubated in simulated uterine fluid (SUF).
The concentrations of cupric ion and indomethacin were analyzed by flame atomic absorption
spectrometer (FAAS) for 250 days and UV 752 spectrophotometer for 300 days, respectively.
Results
The release behavior of cupric ion for three types of Cu-IUDs was biphasic, which
consisted of the initial burst release and then slow and constant release. The release
of cupric ion from the medicated Cu-IUD Yuangong 365 showed a zero-order process.
In vitro release experiment confirmed a sustained release of indomethacin from Yuangong
365 and the release was in accordance with the Weibull equation.
Conclusion
The cupric ion release appears to be more constant in the medicated Cu-IUD than in
the others. In view of the feature of indomethacin release from medicated Cu-IUD,
it is conjectured that the design of this device could be useful to avoid the adverse
effects caused by all Cu-IUDs.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to ContraceptionAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Worldwide use of intrauterine devices for contraception.Contraception. 2007; 75: 2-7
- Study on action of copper ion on rats and rabbits pregnancy.Cr Soc Biol. 1997; 166: 1237-1240
- A preliminary morphometric study on the endometrium from patients treated with indomethacin-releasing copper intrauterine devices.Hum Reprod. 1997; 7: 1563-1566
- Copper corrosion inhibition by triphylmethane derivations in sulphuric acid media.Corro Sci. 2003; 45: 427-447
- The corrosion behavior of copper in simulated uterine fluid.Corros Sci. 1996; 38: 635-641
- Copper release from copper intrauterine devices removed after up to 8 years of use.Contraception. 1993; 47: 349-357
- Corrosion of a new copper-gold or copper-platinum intrauterine device.J Biomed Mater Res. 1982; 16: 785-798
- Corrosion study of copper bearing intrauterine devices (Cu-IUD).Reprod Contracep. 2004; 24: 299-302
- Corrosion behavior of copper/LDPE nanocomposites in simulated uterine solution.Biomaterials. 2005; 26: 2671-2676
- Copper release from copper-T intrauterine devices.Contraception. 1976; 14: 25-38
- Can intrauterine device removals for bleeding or pain be predicted at a one-month follow-up visit?.Contraception. 1998; 58: 357-360
- Cochrane systematic reviews of IUD trials: lessons learned.Contraception. 2007; 75: S55-S59
- A pharmacodynamic study on indomethacin IUD.Reprod Contracept. 2000; 20: 165-171
- A comparative study of Cu380 IUD and TCu 380A IUD.Reprod Contracep. 2000; 20: 26-29
- Preliminary studied on the release of indomethacin from a silastic rubber device and its histocompatibility (in Chinese).Reprod Contracep. 1989; 9: 25-27
- Influence of pH and oxygen on copper corrosion in simulated uterine fluid.Biomaterials. 2002; 23: 667-671
- Study on the indomethacin release in vitro of active Yuangong type drug-releasing copper-bearing intrauterine contraceptive device.Reprod Contracep. 2006; 26: 602-605
- The release of cupric ion in simulated uterine: new material nano-Cu/low-density polyethylene used for intrauterine devices.Contraception. 2004; 70: 153-157
- The corrosion behavior of copper in simulated uterine fluid.Corros Sci. 1996; 38: 635-641
- Contraception through the use of intrauterine ���T��� device. The endouterine copper ���T���.Am J Obstet Gynecol. 1971; 109: 771-774
- A comparative study of menstrual blood loss and haemoglobin changes in women wearing VCu200 IUD containing or not containing indomethacin.Reprod Contracep. 1990; 20: 20-24
- The association between amount of copper on copper-carrying IUDs and their contraceptive efficacy.J Reprod Med. 1973; 11: 209-210
Article info
Publication history
Published online: February 20, 2008
Accepted:
December 8,
2007
Received in revised form:
December 6,
2007
Received:
August 27,
2007
Identification
Copyright
© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
