Abstract
Background
This study compares the risk of breast cancer for levonorgestrel-releasing intrauterine
devices (LNGIUD) versus copper IUDs (CUIUD) in women younger than 50 years of age.
Study Design
Retrospective, population-based, case-control study using cancer registers in Finland
and Germany, powered to exclude a 1.5-fold risk of breast cancer.
Results
Analysis of 5113 breast cancer cases diagnosed 2000���2007 and 20,452 controls ���
matched by year of birth and area of residence ��� yielded relative risk estimates
approaching unity with 95% CI crossing 1.0 for all comparisons, including ever-use
of LNGIUD versus CUIUD (adjusted OR, 0.99; 95% CI, 0.88���1.12) and current use at time of diagnosis (adjusted
OR, 0.85; 95% CI, 0.52���1.39), as well as for sub-analyses by country, age, tumor
characteristics and period, recency and duration of use prior to diagnosis.
Conclusion
This study does not indicate an increased risk of breast cancer for users of LNGIUD. No indications for tumor promotion or tumor induction were found.
Keywords
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Article info
Publication history
Published online: January 10, 2011
Accepted:
November 16,
2010
Received in revised form:
November 7,
2010
Received:
September 27,
2010
Footnotes
���The study was supported by an unconditional grant from Bayer Schering Pharma, Berlin. Bayer Schering Pharma was not involved in the preparation or review of the manuscript.
Identification
Copyright
© 2011 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
