Abstract
Background
We reviewed our experience with adding mifepristone to the protocol for the termination
of pregnancy up to 24 weeks of gestation by intra-amniotic ethacridine lactate.
Study Design
The study consisted of women who presented for the termination of a second-trimester
pregnancy between August 2000 and July 2008.
Results
Of 1245 women who requested a termination of a second-trimester pregnancy, 744 women
underwent the induction of abortion by intra-amniotic ethacridine lactate with mifepristone
(mifepristone group), and 501 received intra-amniotic ethacridine lactate alone (control
group). The proportion of women who delivered within 24 h was 25.94% in the mifepristone
group and 10.18% in the control group (p<.001); the failure rate of abortion was 5.38%
in the mifepristone group and 4.99% in the control group (p<.001). There was no significant
difference in the complication rate between the two groups. The rate of cervical laceration
was 0.54% in the mifepristone group and 0.60% in the control group (p=.9315). The
rate of retained placental tissue was 6.99% in the mifepristone group and 6.19% in
the control group (p=.1112). Nausea was reported by 34.0% of women in the mifepristone
group and none in the control group.
Conclusion
The addition of mifepristone to ethacridine lactate may shorten the induction-to-abortion
time compared with the use of ethacridine lactate alone without increasing the number
of complications.
Keywords
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Article info
Publication history
Published online: July 15, 2011
Accepted:
June 1,
2011
Received in revised form:
May 31,
2011
Received:
December 18,
2010
Identification
Copyright
© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
