Abstract
Background
The aim of the study is to analyze the effect of low estrogen contraceptives (OC)
on oxidative stress (OS) and concomitantly also the changes produced by different
treatments using physiological modulators (PMs) with antioxidant action.
Study Design
Sixty-four female volunteers using a low estrogen OC regimen were analyzed for their
OS status through the reactive oxygen metabolites-derived compounds (d-ROMs) test,
during 5 different cycles (Cycle I to V). Three experiments were performed.
Results
In the first experiment (Cycle I), OS showed almost a constant 50% increase in all
the determinations. In the second experiment (Cycles II and III), the participants
were divided into two groups and treated double-blind with a placebo or with a PM
(MF Templar��) that significantly reduced OS, on average by 69%, while the placebo
had no effect. In the third experiment (Cycles IV and V), the placebo group was divided
into three subgroups, A, B, C and treated, respectively, with MF Templar��, green
tea containing the same amount of catechins present in MF Templar�� or with MF Templar��
devoid of catechins. Only the complete product, MF Templar��, was able to reduce OS
levels, on average by 70%.
Conclusion
We conclude that to control the OS generated by OC, specific types of PMs are needed.
In particular MF Templar�� was able to induce a significant reduction of OS levels.
Keywords
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Article Info
Publication History
Published online: November 14, 2011
Accepted:
September 28,
2011
Received in revised form:
September 16,
2011
Received:
December 7,
2010
Identification
Copyright
© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
