Abstract
Background
The aim of the study is to analyze the effect of low estrogen contraceptives (OC)
on oxidative stress (OS) and concomitantly also the changes produced by different
treatments using physiological modulators (PMs) with antioxidant action.
Study Design
Sixty-four female volunteers using a low estrogen OC regimen were analyzed for their
OS status through the reactive oxygen metabolites-derived compounds (d-ROMs) test,
during 5 different cycles (Cycle I to V). Three experiments were performed.
Results
In the first experiment (Cycle I), OS showed almost a constant 50% increase in all
the determinations. In the second experiment (Cycles II and III), the participants
were divided into two groups and treated double-blind with a placebo or with a PM
(MF Templar��) that significantly reduced OS, on average by 69%, while the placebo
had no effect. In the third experiment (Cycles IV and V), the placebo group was divided
into three subgroups, A, B, C and treated, respectively, with MF Templar��, green
tea containing the same amount of catechins present in MF Templar�� or with MF Templar��
devoid of catechins. Only the complete product, MF Templar��, was able to reduce OS
levels, on average by 70%.
Conclusion
We conclude that to control the OS generated by OC, specific types of PMs are needed.
In particular MF Templar�� was able to induce a significant reduction of OS levels.
Keywords
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References
Cornelli U, Belcaro G, Cesarone MR. Analysis of oxidative status during the mestrual cycle. Am J Physiol, in press.
- A simple test to monitor oxidative stress.Int Angiol. 1999; 18: 127-130
- Assessment of the activity of oral contraceptives (OC) on the levels of oxidative stress and changes in oxidative stress after co-treatment with two different type of physiological modulators with antioxidant action.Contraception. 2011; 84: 418-422
- Benefit and liabilities of vitamin A and carotenoids.J Nutr. 1996; 126: 1208S-1212S
- Bioavailability and antioxidant activity of some food supplements in men and women using the D-Roms test as a marker of oxidative stress.J Nutr. 2001; 131: 3208-3211
- Catechins are bioavailable in men and women drinking black tea throughout the day.J Nutr. 2001; 131: 1731-1737
- Clinical pharmacokinetics of antioxidants and their impact on systemic oxidative stress.Clin Pharmacokinet. 2003; 42: 437-459
- Antioxidant activity of phenolic compounds: from in vitro results to in vivo evidence.Crit Rev Food Sci. 2008; 48: 649-671
- Action of antioxidant complex on the antioxidant power of saliva.Pan Med. 2010; 52: 69-73
- Effect of oral contraception with ethiylestradiol and drospirenone on oxidative stress in women 18-35 years old.Contraception. 2009; 80: 187-193
- Effect of different contraceptive methods on the oxidative status in women aged 40-48 years from ELAN study in the Province of Li��ge- Belgium.Human Reprod. 2007; 22: 2335-2343
- Relaxin as a natural agent for vascular health.Vasc Health Risk Manag. 2008; 4: 515-524
- Modulation of endometrial balance during the menstrual cycle: relation with sex hormones.J Clin Endocrinol Metab. 2002; 87: 2843-2848
- Treatment of Alzheimer's disease with a cholinesterase inhibitor combined with antioxidants.Neurodegenerative Dis. 2010; 7: 193-202
- Antioxidant use in nutraceuticals.Clin Dermat. 2009; 27: 175-194
- MF Afragil�� in the treatment of 34 menopause symptoms: a pilot study.Pan Med. 2010; 52: 49-54
- Effects of green tea and EGCG on cardiovascular and metabolic health.J Am Coll Nutr. 2007; 26: 373S-388S
- Wide distribution of [3H](-) epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue.Carcinogenesis. 1998; 19: 1771-1776
Article info
Publication history
Published online: November 14, 2011
Accepted:
September 28,
2011
Received in revised form:
September 16,
2011
Received:
December 7,
2010
Identification
Copyright
© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
