Despite the high efficacy of the levonorgestrel-releasing intrauterine system (LNG-IUS) in preventing pregnancy, uptake of the intrauterine devices remains low in the United States. Decreasing pain at the time of intrauterine device insertion may be one way to increase interest in this method of contraception.
We conducted a double-blind, placebo-controlled trial, randomizing women to 800 mg ibuprofen or placebo 45 min prior to LNG-IUS insertion to determine effect of ibuprofen on the pain of LNG-IUS insertion.
Eighty-one women completed the study: 44 received ibuprofen, and 37 received placebo. Women in the ibuprofen and placebo groups had similar mean scores for anticipated pain (4.07 and 3.91, respectively; p=.79), pain with tenaculum placement (3.86 and 3.81, respectively; p=.90) and pain with insertion (3.69 and 3.34, respectively; p=.91).
Administration of ibuprofen prophylaxis for LNG-IUS insertion does not decrease pain at the time of insertion.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Contraception
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Contraceptive failure in the United States.Contraception. 2011; 83: 397-404
- Use of contraception in the United States: 1982���2008.Vital Health Stat. 2010; 23: 1-44
- Pain relief with naproxen following insertion of an intrauterine device.J Reprod Med. 1974; 13: 226-231
- Prophylactic use of prostaglandin synthetase inhibitors in connection with IUD insertion.Ugeskr Laeger. 1998; 160: 6958-6961
- Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.Am J Obstet Gynecol. 2006; 195: 1272-1277
- Interventions for pain with intrauterine device insertion.Cochrane Database Syst Rev. 2009; 8: CD007373
Duramed Pharmaceuticals communication.
Bayer Healthcare Pharmaceuticals communication.
- Comparison of pain and time of procedures with two first-trimester abortion techniques performed by residents and faculty.Am J Obstet Gynecol. 2001; 184: 1564-1567
Pharmacia Corporation. Motrin�� ibuprofen tablets, USP.
- Topical anesthesia: a preliminary report.Int J Gynaecol Obstet. 1977; 15: 238-240
- Jet-injection ��� local anesthesia for fitting and removal of IUDs.Contracept Deliv Syst. 1983; 4: 27-32
- Pain relief at insertion and removal of an IUD: a simplified technique for paracervical block.Adv Contracept. 1985; 1: 167-170
- Pain and discomfort perception at IUD insertion ��� effect of short-duration, low volume, intracervical application of two per cent lignocaine gel (Instillagel) ��� a preliminary study.Br J Fam Plann. 1996; 22: 177-180
- Cervical priming with sublingual misoprostol prior to insertion of an intrauterine device in nulliparous women: a randomized controlled trial.Hum Reprod. 2007; 22: 2647-2652
- Vaginal misoprostol prior to insertion of an intrauterine device: an RCT.Hum Reprod. 2011; 26: 323-329
Published online: December 16, 2011
Accepted: October 21, 2011
Received in revised form: October 20, 2011
Received: September 29, 2011
���There was no funding provided for this project.
© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.