Abstract
Background
Despite the high efficacy of the levonorgestrel-releasing intrauterine system (LNG-IUS)
in preventing pregnancy, uptake of the intrauterine devices remains low in the United
States. Decreasing pain at the time of intrauterine device insertion may be one way
to increase interest in this method of contraception.
Study Design
We conducted a double-blind, placebo-controlled trial, randomizing women to 800 mg
ibuprofen or placebo 45 min prior to LNG-IUS insertion to determine effect of ibuprofen
on the pain of LNG-IUS insertion.
Results
Eighty-one women completed the study: 44 received ibuprofen, and 37 received placebo.
Women in the ibuprofen and placebo groups had similar mean scores for anticipated
pain (4.07 and 3.91, respectively; p=.79), pain with tenaculum placement (3.86 and
3.81, respectively; p=.90) and pain with insertion (3.69 and 3.34, respectively; p=.91).
Conclusion
Administration of ibuprofen prophylaxis for LNG-IUS insertion does not decrease pain
at the time of insertion.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to ContraceptionAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Contraceptive failure in the United States.Contraception. 2011; 83: 397-404
- Use of contraception in the United States: 1982���2008.Vital Health Stat. 2010; 23: 1-44
- Pain relief with naproxen following insertion of an intrauterine device.J Reprod Med. 1974; 13: 226-231
- Prophylactic use of prostaglandin synthetase inhibitors in connection with IUD insertion.Ugeskr Laeger. 1998; 160: 6958-6961
- Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.Am J Obstet Gynecol. 2006; 195: 1272-1277
- Interventions for pain with intrauterine device insertion.Cochrane Database Syst Rev. 2009; 8: CD007373
Duramed Pharmaceuticals communication.
Bayer Healthcare Pharmaceuticals communication.
- Comparison of pain and time of procedures with two first-trimester abortion techniques performed by residents and faculty.Am J Obstet Gynecol. 2001; 184: 1564-1567
Pharmacia Corporation. Motrin�� ibuprofen tablets, USP.
- Topical anesthesia: a preliminary report.Int J Gynaecol Obstet. 1977; 15: 238-240
- Jet-injection ��� local anesthesia for fitting and removal of IUDs.Contracept Deliv Syst. 1983; 4: 27-32
- Pain relief at insertion and removal of an IUD: a simplified technique for paracervical block.Adv Contracept. 1985; 1: 167-170
- Pain and discomfort perception at IUD insertion ��� effect of short-duration, low volume, intracervical application of two per cent lignocaine gel (Instillagel) ��� a preliminary study.Br J Fam Plann. 1996; 22: 177-180
- Cervical priming with sublingual misoprostol prior to insertion of an intrauterine device in nulliparous women: a randomized controlled trial.Hum Reprod. 2007; 22: 2647-2652
- Vaginal misoprostol prior to insertion of an intrauterine device: an RCT.Hum Reprod. 2011; 26: 323-329
Article info
Publication history
Published online: December 16, 2011
Accepted:
October 21,
2011
Received in revised form:
October 20,
2011
Received:
September 29,
2011
Footnotes
���There was no funding provided for this project.
Identification
Copyright
© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
