Abstract
Background
Hypertension is a primary cardiovascular risk factor. Oral contraceptives (OCs) may
increase blood pressure and cardiovascular events. We evaluated whether an OC containing
ethynylestradiol (EE) in association with the spironolactone-derived progestin drospirenone
(DRSP) influences 24-h ambulatory blood pressure of normotensive women.
Study Design
Twenty-four-hour blood pressure was measured every 30 min by an ambulatory blood pressure
device in 18 normotensive healthy women prior to and after 6 months of use of an OC
containing 30 mcg EE and 3 mg DRSP.
Results
OC induced no modification in 24-h, nighttime and daytime blood pressure. Heart rate
increased about 4 beats/min in the 24-h (p<.05) and daytime (p<.02) measurements.
Conclusions
In normotensive women, an OC containing 30 mcg EE plus 3 mg DRSP does not modify blood
pressure, and significantly increases 24-h and daytime heart rate. These data suggest
a neutral effect on hypertension-associated cardiovascular risk and point out an unreported
effect on heart rate of which cause and effect require further evaluation.
Keywords
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Article info
Publication history
Published online: December 12, 2012
Accepted:
December 1,
2012
Received in revised form:
November 29,
2012
Received:
October 2,
2012
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.