Abstract
Background
Sino-implant (II) is a low-cost subdermal contraceptive implant containing levonorgestrel
that is currently labeled for 4 years of use. Widely used in China and Indonesia,
it has been little studied elsewhere. We conducted a prospective study of Sino-implant
(II) use by women in Madagascar.
Methods
We enrolled a total of 621 women 18 or older who had Sino-implant (II) inserted on
day of enrollment, some in fixed clinical sites, and some at outreach sites. Half
of the women were scheduled for follow-up visits at 3 months and at 12 months postinsertion
(active follow-up cohort); the other half were advised to return if they desired care
for any problem, thought they were pregnant or wanted the implants removed (passive
surveillance cohort).
Results
No insertion complications were reported. A total of 384 women returned for an earlier
visit, and 351 returned for a later visit, for a total of 419 woman���years of observation.
No postinsertion pregnancies or serious adverse events were observed. Twenty-eight
implant removals were reported by 12 months, a cumulative removal probability of 7.3
per 100 women. Acceptability of the implants was very high, as was satisfaction with
clinic services.
Conclusions
This is the first report on the performance of Sino-implant (II) from outside China
and Indonesia and among the first in the English-language literature. These initial
data from Madagascar indicate a favorable level of safety, effectiveness and acceptability
during the first year of use.
Keywords
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References
- Sino-implant (II) ��� a levonorgestrel-releasing two-rod implant: systematic review of the randomized controlled trials.Contraception. 2010; 81: 197-201
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Article info
Publication history
Published online: March 21, 2013
Accepted:
March 12,
2013
Received in revised form:
March 6,
2013
Received:
December 21,
2012
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
