Abstract
Objective
To evaluate pregnancy rates with 84/7, 21/7, and 24/4 combined oral contraceptives
(COCs).
Study design
Data were obtained from the i3Invision Data MartTM retrospective claims database. Subjects were 15 to 40 years; first prescribed COCs
between January 1, 2006 and April 1, 2011; and continuously insured for ≥1 year. Eighty four over seven users (84/7) were matched 1:1 to 21/7 and 24/4 users.
Results
One-year pregnancy rates were significantly lower with 84/7 than with 21/7 (4.4% vs.
7.3%; p<.0001) and 24/4 (4.4% vs. 6.9%, p<.0001) regimens.
Conclusion
Preliminary results suggest fewer pregnancies with 84/7 versus 21/7 or 24/4 regimens.
Implications
While newer COCs, including 84/7 and 24/4 regimens, potentially improve efficacy and
alter bleeding profiles compared to 21/7 regimens, few data on comparative pregnancy
rates with these regimens are available. In this retrospective claims analysis, real-world
pregnancy rates were lower with 84/7 regimens versus 21/7 and 24/4 regimens.
Keywords
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Article info
Publication history
Published online: September 23, 2013
Accepted:
September 13,
2013
Received in revised form:
September 6,
2013
Received:
July 8,
2013
Footnotes
☆Conflicts of interest: Brandon Howard and ElizaBeth Grubb are employees of Teva Pharmaceuticals, Inc.; Maureen Lage is the managing member of HealthMetrics Outcomes Research and was compensated by Teva Pharmaceuticals for her work on this project.
Identification
Copyright
© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
