Early abortion continues to expand outside of traditional clinics, through telemedicine,
self-managed medication abortion, or in smaller offices that do not specialize in
obstetrical care. Consequently, requiring Rh testing and anti-D immunoglobulin as
part of abortion care is becoming a barrier. As of early 2019, the Society of Family
Planning [
[1]
], the American College of Obstetricians and Gynecologists [
[2]
], and the Society of Obstetricians and Gynecologists of Canada [
[3]
] recommend that all Rh D-negative women receive anti-D immunoglobulin after an induced
abortion, regardless of gestational age or type of procedure. However, the evidence
of clear benefit in early pregnancy, the gestational age at which sensitization might
occur, and the differences between aspiration, sharp curettage, or medication abortion,
are not well established [
[4]
]. Indeed, other guidelines vary. The World Health Organization recommends that where
Rh D-negative status is prevalent and anti-D immunoglobulin is routinely provided,
it should be administered. However, Rh testing is not a requirement for abortion in
any setting [
- Karanth L.
- Jaafar S.H.
- Kanagasabai S.
- Nair N.S.
- Barua A.
Anti-D administration after spontaneous miscarriage for preventing rhesus alloimmunisation.
Cochrane Database Syst Rev. 2013; CD009617https://doi.org/10.1002/14651858.CD009617.pub2
[5]
]. Dutch guidelines do not recommend testing and treating Rh D-negative women until
the pregnancy is greater than 49 days from the last menstrual period [
[6]
]. The British Committee for Standards in Hematology recommends no treatment for spontaneous
complete miscarriage below 12 weeks but treatment for therapeutic termination of pregnancy
regardless of gestational age [
- Dutch Association of Abortion Specialists (NgvA)
Guideline for the treatment of women undergoing termination of pregnancy.
https://www.bloemenhove.nl/en/professionals/quality/guidelines;
Date: 2011
Date accessed: January 15, 2019
[7]
]. Danish guidelines state that routine anti-D immunoglobulin treatment does not appear
to be necessary for pregnancies of less than 8 weeks gestation [
[8]
]. In 1997, the Swedish Board of Health and Welfare recommended against the use of
anti-D immunoglobulin in early spontaneous or medication abortion [
[9]
].To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to ContraceptionAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Contraception. 2014; 89: 148-161https://doi.org/10.1016/j.contraception.2014.11.004
- Practice bulletin no. 181: prevention of Rh D alloimmunization.Obstet Gynecol. 2017; 130: e57-e70https://doi.org/10.1097/AOG.0000000000002232
- No. 133-prevention of Rh alloimmunization.J Obstet Gynaecol Can. 2018; 40: e1-e10https://doi.org/10.1016/j.jogc.2017.11.007
- Anti-D administration after spontaneous miscarriage for preventing rhesus alloimmunisation.Cochrane Database Syst Rev. 2013; CD009617https://doi.org/10.1002/14651858.CD009617.pub2
- Safe abortion: Technical and policy guidance for health systems.2nd ed. World Health Organization, Geneva2012
- Guideline for the treatment of women undergoing termination of pregnancy.https://www.bloemenhove.nl/en/professionals/quality/guidelines;Date: 2011Date accessed: January 15, 2019
- BCSH guideline for the use of anti-D immunoglobulin for the prevention of haemolytic disease of the fetus and newborn.Transfus Med. 2014; 24: 8-20
- Kirurgisk provokeret abort i første trimester.2014
- Rh-prophylaxis in early abortion.Acta Obstet Gynecol Scand. 2003; 82: 892-903
- Persistent fetal hemoglobin in maternal circulation complicating the diagnosis of fetomaternal hemorrhage.Obstet Gynecol. 2005; 105: 872-874https://doi.org/10.1097/01.AOG.0000141646.58884.09
- Is Rh immune globulin needed in early first-trimester abortion? A review.Am J Obstet Gynecol. 2003; 188: 623-627https://doi.org/10.1067/mob.2003.208
- Do Rh-negative women with an early spontaneous abortion need Rh immune prophylaxis?.Am J Obstet Gynecol. 1972; 113: 158-165https://doi.org/10.1016/0002-9378(72)90765-X
- Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin. Irish hepatology research group.N Engl J Med. 1999; 340: 1228-1233https://doi.org/10.1056/NEJM199904223401602
- Guidelines on the prophylactic use of Rh D immunoglobulin (anti-D) in obstetrics.
- Anti-D administration in early pregnancy - time for a new protocol.Aust N Z J Obstet Gynaecol. 1995; 35: 385-387
- Sensitivity of fetal RHD screening for safe guidance of targeted anti-D immunoglobulin prophylaxis: prospective cohort study of a nationwide programme in the Netherlands.BMJ. 2016; 355: i5789https://doi.org/10.1136/bmj.i5789: 10.1136/bmj.i5789
- The transplacental passage of foetal red blood-cells and the pathogenesis of Rh immunisaztion during pregnancy.Lancet. 1963; 2: 489-493https://doi.org/10.1016/S0140-6736(63)90228-9
- Suppression of Rh-immunization by passively administered anti-Rh.Br J Haematol. 1968; 14: 1-4
- Transplacental haemorrhage after abortion.Lancet. 1970; 1: 631-634
- A highly sensitive flow cytometry protocol shows fetal red blood cell counts in the first-trimester maternal circulation well below the threshold for Rh sensitization.Contraception. 2018; 98: 332
- Can we safely stop testing for Rh status and immunizing Rh-negative women having early abortions? A comparison of Rh alloimmunization in Canada and the Netherlands.Contraception X. 2019; 1: 100001
Article info
Publication history
Published online: March 10, 2019
Identification
Copyright
© 2019 Elsevier Inc. All rights reserved.