Abstract
Objectives
Examine intrauterine device (IUD) switching or discontinuation up to 6 months after
participant-masked randomization to different IUDs.
Study design
Participants were randomized 1:1 to the copper T380A or levonorgestrel 52 mg IUD for
emergency contraception and informed they could switch IUD type without cost at any
time.
Results
Of the 327 subjects allocated to the levonorgestrel IUD, 7 (2.1%) switched their IUD
type by 6 months versus 18 (5.5%) of the 328 copper IUD users (RR: 0.4 [95% CI: 0.2,
0.9], p = 0.03). Six-month IUD discontinuation occurred in 34 (10.4%) levonorgestrel and
35 (10.7%) copper IUD users.
Conclusion
Individuals randomly assigned to IUD type at presentation for emergency contraception
continue their assigned IUDs at high rates over 6 months.
Implications
While many recruited individuals declined enrollment, those who accepted randomization
had high continuation rates; the high continuation and low cross-over supports using
IUD randomization as a tool for future investigation. Participants’ similar rates
of and reasons for switching and discontinuation by IUD type over the study period
may impact clinical counseling.
Keywords
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Article Info
Publication History
Published online: October 11, 2022
Accepted:
September 14,
2022
Received in revised form:
September 13,
2022
Received:
February 28,
2022
Publication stage
In Press Corrected ProofFootnotes
ClinicalTrials.gov Identifier: NCT02175030
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
