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Case Reports|Articles in Press, 109994

Allergic and Infectious complications of Etonogestrel Implant Placements: A Case Series

      Abstract

      Patients rarely experience complications at time of Etonogestrel subdermal contraceptive implant placement. Few case reports describe infection or allergy as a complication at time of implant insertion. In this case series, we discuss three infections and one allergic reaction following Etonogestrel implant placement, review 6 previous case reports of 8 cases of infection or allergy and discuss management of these complications. We highlight differential diagnosis when encountering a placement complication, considerations of dermatologic conditions when placing Etonogestrel implants, and discuss when to consider removal of the implant when a complication occurs.

      Keywords

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      References

      1. Nexplanon and Cellulitis, a phase IV clinical study of FDA data - eHealthMe [Internet]. [cited 2022 Aug 30]. Available from: 〈https://www.ehealthme.com/ds/nexplanon/cellulitis/〉

        • Rocca M.L.
        • Palumbo A.R.
        • Visconti F.
        • Di Carlo C.
        Safety and Benefits of Contraceptives Implants: A Systematic Review.
        Pharmaceuticals. 2021; 14 (Jun 8): 548
      2. Nexplanon (etonogestrel implant) [Internet]. US Food and Drug Administration; 2012 [cited 2022 Aug 25]. Available from: 〈https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021529s011lbl.pdf〉

      3. Partridge R. , Bush J. Infections post-Nexplanon® insertion. J Fam Plann Reprod Health Care. 2013/09/26 ed. 2013 Oct;39(4):309–10.

        • Richold J.
        Infection 10 months after insertion of Nexplanon implant.
        BMJ Sex Reprod Health. 2018 Jan; 44 (2017/11/19 ed): 72
        • Chaudhry F.
        Adverse reaction to Nexplanon(R).
        (2013/06/20 ed.)J Fam Plann Reprod Health Care. 39. 2013 Jul: 231-232 (2013/06/20 ed.)
        • Sullivan M.J.
        Allergy to nexplanon®.
        (2012/10/03 ed.)J Fam Plann Reprod Health Care. 38. 2012 Oct: 272 (2012/10/03 ed.)
        • Pedroso C.
        • Martins I.
        • Palma F.
        • Machado A.I.
        Implant site Nexplanon reaction?.
        (2015/05/09 ed)BMJ Case Rep. 7. 2015 May: 2015 (2015/05/09 ed)
        • Serati M.
        • Bogani G.
        • Kumar S.
        • Cromi A.
        • Ghezzi F.
        Delayed-type hypersensitivity reaction against Nexplanon®.
        Contraception. 2015 Jan; 91 (2014/10/07 ed): 91-92
        • Agha R.A.
        • Sohrabi C.
        • Mathew G.
        • Franchi T.
        • Kerwan A.
        • O’Neill N.
        • et al.
        The PROCESS 2020 Guideline: Updating Consensus Preferred Reporting Of CasE Series in Surgery (PROCESS) Guidelines.
        Int J Surg. 2020; 84 (Dec 1): 231-235
        • Reed S.
        • Do Minh T.
        • Lange J.A.
        • Koro C.
        • Fox M.
        • Heinemann K.
        Real world data on Nexplanon® procedure-related events: final results from the Nexplanon Observational Risk Assessment study (NORA). Contraception.
        . 2019 Jul; 100 (2019/04/14 ed): 31-36
        • Gong J.Q.
        • Lin L.
        • Lin T.
        • Hao F.
        • Zeng F.Q.
        • Bi Z.G.
        • et al.
        Skin colonization by Staphylococcus aureus in patients with eczema and atopic dermatitis and relevant combined topical therapy: a double-blind multicentre randomized controlled trial.
        Br J Dermatol. 2006 Oct; 155: 680-687
        • Ayoub F.
        • Quirke M.
        • Conroy R.
        • Hill A.
        Chlorhexidine-alcohol versus povidone-iodine for pre-operative skin preparation: A systematic review and meta-analysis.
        Int J Surg Open. 2015 Jan 1; 1: 41-46
        • Muroi N.
        • Nishibori M.
        • Fujii T.
        • Yamagata M.
        • Hosoi S.
        • Nakaya N.
        • et al.
        Anaphylaxis from the carboxymethylcellulose component of barium sulfate suspension.
        N Engl J Med. 1997 Oct 30; 337: 1275-1277
      4. FSRH Clinical Guideline: Progestogen-only Implant (February 2021) - Faculty of Sexual and Reproductive Healthcare [Internet]. [cited 2022 Jul 28]. Available from: 〈https://www.fsrh.org/standards-and-guidance/documents/cec-ceu-guidance-implants-feb-2014/〉

        • Stevens D.L.
        • Bisno A.L.
        • Chambers H.F.
        • Dellinger E.P.
        • Goldstein E.J.
        • Gorbach S.L.
        • et al.
        Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America.
        Clin Infect Dis. 2014 Jul 15; 59 (2014/06/21 ed): 147-159