Advertisement

Norplant® implants and cardiovascular disease

      Abstract

      A 1995 publication on serious adverse events in users of Norplant® implants submitted to the Food and Drug Administration’s MedWatch Spontaneous Reporting System reported 14 hospitalizations for stroke in Norplant users. This number was higher than expected. This is a report on the association of current use of Norplant implants with stroke and myocardial infarction (MI) based on a pooled analysis of data from two population-based, case-control studies conducted in the US. All data collection for these two studies occurred after approval of Norplant implants for marketing in the US in December 1990. The methods of the individual studies are detailed in prior publications.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Contraception
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

      1. Wysowski DK, Green L. Serious adverse events in Norplant implants users reported to the Food and Drug Administration’s MedWatch Spontaneous Reporting System. Obstet Gynecol 1995;85:538–42.

        • Sidney S.
        • Petitti D.B.
        • Quesenberry Jr, C.P.
        • Klatsky A.L.
        • Ziel H.K.
        • Wolf S.
        Myocardial infarction in users of low-dose oral contraceptives.
        Obstet Gynecol. 1996; 88: 939-944
        • Petitti D.B.
        • Sidney S.
        • Bernstein A.
        • Wolf S.
        • Quesenberry C.
        • Ziel H.K.
        Stroke in users of low-dose oral contraceptives.
        N Engl J Med. 1996; 335: 8-15
        • Schwartz S.M.
        • Siscovick D.S.
        • Longstreth Jr, W.T.
        • et al.
        Use of low-dose oral contraceptives and stroke in young women.
        Ann Intern Med. 1997; 127: 596-603