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Antispermatogenic effect of Achillea millefolium L. in mice

      Abstract

      The effect of an ethanolic extract (200 mg/kg/day, intraperitoneally, for 20 days) and a hydroalcoholic extract (300 mg/kg/day, orally, for 30 days) of Achillea millefolium L. (yarrow) flowers on the spermatogenesis of Swiss mice was studied by evaluating morphologic characteristics with the light and electron microscopes. The alterations observed were exfoliation of immature germ cells, germ cell necrosis, and seminiferous tubule vacuolization. Animals treated with the extracts had an increased number of metaphases in the germ epithelium that might be due to cytotoxic substances or substances stimulating cell proliferation.

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      References

        • Chandler R.F.
        • Hooper S.N.
        • Harvey M.J.
        Ethnobotany and phytochemistry of yarrow, Achillea millefolium, Compositae.
        Econ Bot. 1982; 36: 203-223
        • De Laszlo H.
        • Henshaw P.S.
        Plant materials used by primitive peoples to affect fertility.
        Science. 1954; 119: 626-631
        • Barnes C.S.
        • Price J.R.
        • Hughes R.L.
        An examination of some reputed antifertility plants.
        Lloydia. 1975; 38: 135-140
        • Lobl T.J.
        • Porteus S.E.
        Antispermatogenic effects of 5-aminoindazole in rats.
        J Reprod Fertil. 1977; 50: 371-372
        • Haider S.G.
        • Passia D.
        • Chen K.Q.
        • Stumpf W.E.
        Reversible changes in rat spermatogenesis induced by an antifertility substance (gossypol).
        Acta Histochem. 1985; 77: 185-191
        • Qian S.Z.
        • Zhong C.Q.
        • Xu Y.
        Effect of Trypterygium wilfordii on the fertility of rats.
        Contraception. 1986; 33: 105-110
        • Abdi S.H.M.
        • Hasan W.
        Effect of testosterone on the histological structure of the testis of adult albino rats.
        Indian J Med Res. 1973; 61: 1207-1211
        • Bustos-Obregon E.
        • Feito R.
        The effect of vinblastine sulfate on rat spermatogenesis.
        Arch Biol. 1974; 85: 353-364
        • Rücker G.
        • Walter R.D.
        • Manns D.
        • Mayer R.
        Antimalarial activity of some natural peroxides.
        Planta Med. 1991; 57: 295-296
        • Majumdar S.K.
        • Udelsman R.
        Fine structure of mouse testes following intraperitoneal treatment with 5-thio-D-glucose.
        J Heredity. 1979; 70: 194-198