Abstract
Intrauterine devices (IUD) provide effective contraception. The current study evaluates
the concentration of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the
intrauterine fluid of postmenopausal women using an intrauterine delivery system releasing
progesterone (IDS-P). Intrauterine fluid was obtained by lavage, and IL-6 and TNF-α
were analyzed using an enzyme-linked immunosorbent assay (ELISA). Statistical analysis
was performed with a one-way analysis of variance (ANOVA).
Intrauterine fluid IL-6 levels were 33.6 vs 6.09 pg/sample IDS-P vs no IDS-P (p =
0.0301). Intrauterine TNF-α levels for women using the IDS-P were higher than in nonusers,
but the differences did not reach statistical significance. IL-6 and TNF-α levels
were increased in the intrauterine cavity of postmenopausal women with an IDS-P. These
data suggest that secreted cytokines could be a potential mechanism of IUD contraceptive
efficacy.
Keywords
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Article info
Publication history
Accepted:
February 22,
1999
Received in revised form:
February 9,
1999
Received:
September 4,
1998
Identification
Copyright
© 1999 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.
