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Interleukin-6 and tumor necrosis factor-α concentrations in the intrauterine cavity of postmenopausal women using an intrauterine delivery system releasing progesterone

A possible mechanism of action of the intrauterine device
  • David F Archer
    Correspondence
    Name and address for correspondence: David F. Archer, MD, The Clinical Research Center, The Jones Institute for Reproductive Medicine, 601 Colley Avenue, Norfolk, VA 23507; Tel.: (757) 446-7444; Fax: (757) 446-8998
    Affiliations
    The Clinical Research Center, Department of Obstetrics and Gynecology, The Eastern Virginia Medical School, Norfolk, Virginia, USA
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  • Keri R DeSoto
    Affiliations
    The Clinical Research Center, Department of Obstetrics and Gynecology, The Eastern Virginia Medical School, Norfolk, Virginia, USA
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  • Jay M Baker
    Affiliations
    The Clinical Research Center, Department of Obstetrics and Gynecology, The Eastern Virginia Medical School, Norfolk, Virginia, USA
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      Abstract

      Intrauterine devices (IUD) provide effective contraception. The current study evaluates the concentration of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the intrauterine fluid of postmenopausal women using an intrauterine delivery system releasing progesterone (IDS-P). Intrauterine fluid was obtained by lavage, and IL-6 and TNF-α were analyzed using an enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed with a one-way analysis of variance (ANOVA).
      Intrauterine fluid IL-6 levels were 33.6 vs 6.09 pg/sample IDS-P vs no IDS-P (p = 0.0301). Intrauterine TNF-α levels for women using the IDS-P were higher than in nonusers, but the differences did not reach statistical significance. IL-6 and TNF-α levels were increased in the intrauterine cavity of postmenopausal women with an IDS-P. These data suggest that secreted cytokines could be a potential mechanism of IUD contraceptive efficacy.

      Keywords

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